Gene expression profiles of mitochondria-endoplasmic reticulum tethering in human gingival fibroblasts in response to periodontal pathogens.

Aral K., Milward M. R., Cooper P. R.

Archives of oral biology, cilt.128, ss.105173, 2021 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 128
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1016/j.archoralbio.2021.105173
  • Dergi Adı: Archives of oral biology
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database
  • Sayfa Sayıları: ss.105173
  • Anahtar Kelimeler: Periodontal disease, Endoplasmic reticulum, Porphyromonas gingivalis, Fusobacterium nucleatum, Mitochondria, Gingival fibroblasts, PORPHYROMONAS-GINGIVALIS, CELL-DEATH, INFLAMMATORY RESPONSE, STRESS-RESPONSE, CALCIUM, ER, DEGRADATION, GROWTH, IEX-1
  • İnönü Üniversitesi Adresli: Evet

Özet

Objective: The current study aimed to elucidate the potential involvement of mitochondria-endoplasmic reticulum contact genes in the pathogenesis of periodontal disease by monitoring levels of contact associated genes including Mitofusion 1 (MFN1) and MFN2, inositol 1,4,5-trisphosphate receptor (IP3R), chaperone glucoseregulated protein 75 (GRP75), sigma non-opioid intracellular receptor 1 (SIGMAR1) and phosphate and tensin homolog induced putative kinase 1 (PINK1) in human gingival fibroblasts in response to periodontal pathogens Fusobacterium nucleatum (F. nucleatum) and Porphyromonas gingivalis (P. gingivalis) in vitro.