Curcumin protects against testis-specific side effects of irinotecan

UYANIK Ö., GÜRBÜZ Ş., Ciftci O., Oguzturk H., Aydin M., ÇETİN A., ...Daha Fazla

EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES, cilt.25, sa.23, ss.7440-7448, 2021 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 25 Sayı: 23
  • Basım Tarihi: 2021
  • Dergi Adı: EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.7440-7448
  • Anahtar Kelimeler: Irinotecan, Testis, Curcumin, Rat, SN-38, INHIBITION, MECHANISMS, APOPTOSIS, SYSTEM, CELLS
  • İnönü Üniversitesi Adresli: Evet

Özet

OBJECTIVE: Irinotecan (IR/CPT-11) is a semisynthetic, water-soluble derivative of the alkaloid camptothecin. It is a topoisomerase I group antineoplastic drug commonly used for the treatment of many cancer types, although it has side effects in tissues such as the testis. Curcumin (CRC) is a polyphenol compound produced from the Indian saffron root; it is used as food colouring and food flavouring. This study examined the testis-specific side effects of IR and the ability of CRC to protect against these side effects.