Synthesis, structural characterization and anti-carcinogenic activity of new cyclotriphosphazenes containing dioxybiphenyl and chalcone groups

Gorgulu A. O. , Koran K., Ozen F., TEKİN S. , SANDAL S.

JOURNAL OF MOLECULAR STRUCTURE, cilt.1087, ss.1-10, 2015 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 1087
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1016/j.molstruc.2015.01.033
  • Sayfa Sayıları: ss.1-10


2,2-Dichloro-4,4,6,6-bis[spiro(2',2 ''-dioxy-1',1 ''-biphenylyl]cyclotriphosphazene (2) was synthesized from hexachlorocyclotriphosphazene (HCCP) and 2,2'-dihydroxybiphenyl. The mixed substituent chalcone/dioxybiphenyl cyclophosphazenes (2a-h) were obtained from the reactions of (2) with hydroxy chalcone compounds in K2CO3/acetone system. The chalcone-cyclophosphazene compounds were characterized by elemental analysis, FT-IR, H-1, C-13, P-31 NMR techniques. In vitro anti-carcinogenic activities of all compounds were determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MU) assay. Anti-carcinogenic activity of the compounds (2a-h) against androgen-dependent (LNCaP) and independent (PC-3) human prostate cancer cell lines were investigated. Our results indicate that the chalcone-phosphazene compounds (2a-h) have anti-carcinogenic activity on PC-3 and LNCaP cell lines (p < 0.05). The effective dose of the compounds was determined as 100 mu M. (C) 2015 Elsevier B.V. All rights reserved.