Synthesis, Characterization and Microwave-Promoted Catalytic Activity of Novel N-phenylbenzimidazolium Salts in Heck-Mizoroki and Suzuki-Miyaura Cross-Coupling Reactions under Mild Conditions

Yilmaz, ÜLKÜ; KÜÇÜKBAY, HASAN; Deniz, Selma; ŞİRECİ, NİHAT

doi:10.3390/molecules18032501

Synthesis, Characterization and Microwave-Promoted Catalytic Activity of Novel N-phenylbenzimidazolium Salts in Heck-Mizoroki and Suzuki-Miyaura Cross-Coupling Reactions under Mild Conditions

Yilmaz U., KÜÇÜKBAY H., Deniz S., ŞİRECİ N.

MOLECULES, cilt.18, sa.3, ss.2501-2517, 2013 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 18 Sayı: 3
Basım Tarihi: 2013
Doi Numarası: 10.3390/molecules18032501
Dergi Adı: MOLECULES
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.2501-2517
Anahtar Kelimeler: N-phenylbenzimidazoles, Suzuki-Miyaura reaction, Heck-Mizoroki reaction, microwaves, NHC-precursor, HETEROCYCLIC CARBENE, PALLADIUM CATALYSIS, ORGANIC-SYNTHESIS, DRUG DISCOVERY, ARYL CHLORIDES, C-C, WATER, COMPLEXES, PRECATALYSTS, CHEMISTRY
İnönü Üniversitesi Adresli: Evet

Özet

A number of novel benzimidazolium salts having aryl substituents such as N-phenyl, 4-chlorophenyl and various alkyl substituents were synthesized. Their microwave-assisted catalytic activities were evaluated in Heck-Mizoroki and Suzuki-Miyaura cross-coupling reactions using a catalytic system consisting of Pd(OAc)(2)/K2CO3 in DMF/H2O under mild reaction conditions with consistent high yields, except those of 2-bromopyridine.