Synthesis, Characterization and Microwave-Promoted Catalytic Activity of Novel N-phenylbenzimidazolium Salts in Heck-Mizoroki and Suzuki-Miyaura Cross-Coupling Reactions under Mild Conditions

Yilmaz U., KÜÇÜKBAY H., Deniz S., ŞİRECİ N.

MOLECULES, vol.18, no.3, pp.2501-2517, 2013 (SCI-Expanded, Scopus) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 18 Issue: 3
  • Publication Date: 2013
  • Doi Number: 10.3390/molecules18032501
  • Journal Name: MOLECULES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.2501-2517
  • Keywords: N-phenylbenzimidazoles, Suzuki-Miyaura reaction, Heck-Mizoroki reaction, microwaves, NHC-precursor, HETEROCYCLIC CARBENE, PALLADIUM CATALYSIS, ORGANIC-SYNTHESIS, DRUG DISCOVERY, ARYL CHLORIDES, C-C, WATER, COMPLEXES, PRECATALYSTS, CHEMISTRY
  • Inonu University Affiliated: Yes

Abstract

A number of novel benzimidazolium salts having aryl substituents such as N-phenyl, 4-chlorophenyl and various alkyl substituents were synthesized. Their microwave-assisted catalytic activities were evaluated in Heck-Mizoroki and Suzuki-Miyaura cross-coupling reactions using a catalytic system consisting of Pd(OAc)(2)/K2CO3 in DMF/H2O under mild reaction conditions with consistent high yields, except those of 2-bromopyridine.