Synthesis, microwave-promoted catalytic activity in Suzuki-Miyaura cross-coupling reactions and antimicrobial properties of novel benzimidazole salts bearing trimethylsilyl group
APPLIED ORGANOMETALLIC CHEMISTRY, cilt.25, sa.5, ss.366-373, 2011 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 25 Sayı: 5
- Basım Tarihi: 2011
- Doi Numarası: 10.1002/aoc.1772
- Dergi Adı: APPLIED ORGANOMETALLIC CHEMISTRY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.366-373
- Anahtar Kelimeler: benzimidazole salt, carbene, palladium catalysis, coupling reaction, Suzuki-Miyaura coupling, microwave, antimicrobial activity, CARBENE COMPLEXES, SUBSTITUTED BENZIMIDAZOLE, ARYL CHLORIDES, PALLADIUM, HECK, ANTIBACTERIAL, PRECATALYSTS, DERIVATIVES, SYSTEM, WATER
- İnönü Üniversitesi Adresli: Evet
Özet
A mixture of benzimidazole salts (2-7), Pd(OAc)(2) and K2CO3 in DMF-H2O catalyzes the Suzuki-Miyaura cross-coupling reactions promoted by microwave irradiation resulting in high yield within a short time. In particular, the yield of the Suzuki-Miyaura reactions with aryl bromides was found to be nearly quantitative. The synthesized benzimidazole salts (2-7) were identified by H-1-C-13, NMR, IR spectroscopic methods and microanalysis. The molecular structure of 1 was determined by X-ray crystallography. The antibacterial and antifungal activities of the novel benzimidazole derivatives (1-7) were also tested against standard strains. Copyright (C) 2011 John Wiley & Sons, Ltd.