Synthesis, microwave-promoted catalytic activity in Suzuki-Miyaura cross-coupling reactions and antimicrobial properties of novel benzimidazole salts bearing trimethylsilyl group

Yilmaz U., KÜÇÜKBAY H., Sireci N., AKKURT M., GÜNAL S., DURMAZ R., ...Daha Fazla

APPLIED ORGANOMETALLIC CHEMISTRY, cilt.25, sa.5, ss.366-373, 2011 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 25 Sayı: 5
  • Basım Tarihi: 2011
  • Doi Numarası: 10.1002/aoc.1772
  • Dergi Adı: APPLIED ORGANOMETALLIC CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.366-373
  • Anahtar Kelimeler: benzimidazole salt, carbene, palladium catalysis, coupling reaction, Suzuki-Miyaura coupling, microwave, antimicrobial activity, CARBENE COMPLEXES, SUBSTITUTED BENZIMIDAZOLE, ARYL CHLORIDES, PALLADIUM, HECK, ANTIBACTERIAL, PRECATALYSTS, DERIVATIVES, SYSTEM, WATER
  • İnönü Üniversitesi Adresli: Evet

Özet

A mixture of benzimidazole salts (2-7), Pd(OAc)(2) and K2CO3 in DMF-H2O catalyzes the Suzuki-Miyaura cross-coupling reactions promoted by microwave irradiation resulting in high yield within a short time. In particular, the yield of the Suzuki-Miyaura reactions with aryl bromides was found to be nearly quantitative. The synthesized benzimidazole salts (2-7) were identified by H-1-C-13, NMR, IR spectroscopic methods and microanalysis. The molecular structure of 1 was determined by X-ray crystallography. The antibacterial and antifungal activities of the novel benzimidazole derivatives (1-7) were also tested against standard strains. Copyright (C) 2011 John Wiley & Sons, Ltd.