Effects of apelin on reproductive functions: relationship with feeding behavior and energy metabolism

TEKİN S. , Erden Y., SANDAL S. , Onalan E. E. , OZYALIN F., Ozen H., ...Daha Fazla

ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY, cilt.123, ss.9-15, 2017 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 123 Konu: 1
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1080/13813455.2016.1211709
  • Sayfa Sayıları: ss.9-15


Apelin is an adipose tissue derived peptidergic hormone. In this study, 40 male Sprague-Dawley rats were used (four groups; n=10). Apelin-13 at three different dosages (1, 5 and 50g/kg) was given intraperitoneally while the control group received vehicle the same route for a period of 14 days. In results, apelin-13 caused significant decreases in serum testosterone, luteinizing hormone and follicle-stimulating hormone levels (p<0.05). Administration of apelin-13 significantly increased body weights, food intake, serum low-density lipoprotein and total cholesterol levels (p<0.05), but caused significant decreases in high-density lipoprotein levels (p<0.05). Serum glucose and triglyceride levels were not significantly altered by apelin-13 administration. Significant decreases in both uncoupling protein (UCP)-1 levels in the white and brown adipose tissues and UCP-3 levels in the biceps muscle (p<0.05) were noted. The findings of the study suggest that apelin-13 may not only lead to obesity by increasing body weight but also cause infertility by suppressing reproductive hormones.