An experimental study on the use of lycopene to prevent infertility due to acute oxidative ovarian damage caused by a single high dose of methotrexate

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Turkler C., Onat T., Yildirim E., Kaplan S., YAZICI G. N., MAMMADOV R., ...Daha Fazla

ADVANCES IN CLINICAL AND EXPERIMENTAL MEDICINE, cilt.29, sa.1, ss.5-11, 2020 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 29 Sayı: 1
  • Basım Tarihi: 2020
  • Doi Numarası: 10.17219/acem/111809
  • Dergi Adı: ADVANCES IN CLINICAL AND EXPERIMENTAL MEDICINE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.5-11
  • Anahtar Kelimeler: methotrexate, infertility, oxidative stress, rat, lycopene, LIPID-PEROXIDATION, RAT OVARY, PARAMETERS, RESERVE, CELLS, WOMEN, SERUM, ACID
  • İnönü Üniversitesi Adresli: Hayır

Özet

Background. Methotrexate (MTX) is an antineoplastic agent, which increases the level of reactive oxygen species (ROS) and decreases the level of antioxidants. Lycopene, is a potent antioxidant, which is used because of its protective effect against tissue damage.