Ginkgo biloba inhibits bleomycin-induced lung fibrosis in rats

Iraz M., Erdogan H., Kotuk M., Yagmurca M., Kilic T., Ermis H., ...Daha Fazla

PHARMACOLOGICAL RESEARCH, cilt.53, sa.3, ss.310-316, 2006 (SCI-Expanded, Scopus)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 53 Sayı: 3
  • Basım Tarihi: 2006
  • Doi Numarası: 10.1016/j.phrs.2005.12.009
  • Dergi Adı: PHARMACOLOGICAL RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.310-316
  • Anahtar Kelimeler: bleomycin, lung fibrosis, Ginkgo biloba, INDUCED PULMONARY-FIBROSIS, OXIDATIVE STRESS, N-ACETYLCYSTEINE, EXTRACT EGB-761, HIGH-ALTITUDE, ANTIOXIDANT, GLUTATHIONE, ERDOSTEINE
  • İnönü Üniversitesi Adresli: Evet

Özet

Oxidative stress has been implicated in the pathogenesis of bleomycin-induced lung fibrosis and many antioxidant agents have been studied for prevention and treatment of the disease in animals and humans. We therefore examined whether Ginkgo biloba (Gb), a flavonoid-rich antioxidant, inhibits bleomycin-induced lung fibrosis in rats.