Synthesis of Co/Co3O4 Heterostructure in N-Doped Porous, Amorphous Carbon: A Superior Electrochemical Sensor for Sensitive Determination of Alectinib in Various Fluids


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Yaşar S.

ACS OMEGA, cilt.9, ss.44282-44292, 2024 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 9
  • Basım Tarihi: 2024
  • Doi Numarası: 10.1021/acsomega.4c04821
  • Dergi Adı: ACS OMEGA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Directory of Open Access Journals
  • Sayfa Sayıları: ss.44282-44292
  • İnönü Üniversitesi Adresli: Evet

Özet

Highly crystallized Co and Co3O4 nanoparticles embedded in
an N-doped amorphous carbon matrix have been successfully fabricated by the
molten-salt-assisted method using KClO3 and zeolitic imidazolate framework-
12 (ZIF-12). Pyrolysis of ZIF-12 with different concentrations of KClO3 leads
to embedded Co and Co3O4 nanoparticles in a conductive amorphous carbon
network. The impact of salt concentration on the morphology and
electrochemical performance of these composites was investigated for
electrochemical sensor applications. By employing a straightforward and
efficient technHighly crystallized Co and Co3O4 nanoparticles embedded in
an N-doped amorphous carbon matrix have been successfully fabricated by the
molten-salt-assisted method using KClO3 and zeolitic imidazolate framework-
12 (ZIF-12). Pyrolysis of ZIF-12 with different concentrations of KClO3 leads
to embedded Co and Co3O4 nanoparticles in a conductive amorphous carbon
network. The impact of salt concentration on the morphology and
electrochemical performance of these composites was investigated for
electrochemical sensor applications. By employing a straightforward and
efficient technique, Co/Co3O4 heterostructures were successfully synthesized
in N-doped porous amorphous carbon. The Co/Co3O4 carbon hetero-
structures were optimized by varying the salt concentration, resulting in a
significant electrochemical sensor performance for detecting ALC in both bulk
and biological fluids. The sensor demonstrates excellent sensitivity (62.97
nmol/L) and selectivity toward ALC, with a wide linear range (0.22 μM) and a low detection limit (18.89 nM). Furthermore, it
displays remarkable stability and reproducibility, positioning it as a strong contender for practical use in pharmaceutical analysis and
biomedical research. This study presents a significant advancement in electrochemical sensing technology and underscores the
potential of Co/Co3O4 heterostructures in the development of high-performance sensors for detecting bioactive compounds in
complex matricesHighly crystallized Co and Co3O4 nanoparticles embedded in
an N-doped amorphous carbon matrix have been successfully fabricated by the
molten-salt-assisted method using KClO3 and zeolitic imidazolate framework-
12 (ZIF-12). Pyrolysis of ZIF-12 with different concentrations of KClO3 leads
to embedded Co and Co3O4 nanoparticles in a conductive amorphous carbon
network. The impact of salt concentration on the morphology and
electrochemical performance of these composites was investigated for
electrochemical sensor applications. By employing a straightforward and
efficient technique, Co/Co3O4 heterostructures were successfully synthesized
in N-doped porous amorphous carbon. The Co/Co3O4 carbon hetero-
structures were optimized by varying the salt concentration, resulting in a
significant electrochemical sensor performance for detecting ALC in both bulk
and biological fluids. The sensor demonstrates excellent sensitivity (62.97
nmol/L) and selectivity toward ALC, with a wide linear range (0.22 μM) and a low detection limit (18.89 nM). Furthermore, it
displays remarkable stability and reproducibility, positioning it as a strong contender for practical use in pharmaceutical analysis and
biomedical research. This study presents a significant advancement in electrochemical sensing technology and underscores the
potential of Co/Co3O4 heterostructures in the development of high-performance sensors for detecting bioHighly crystallized Co and Co3O4 nanoparticles embedded in
an N-doped amorphous carbon matrix have been successfully fabricated by the
molten-salt-assisted method using KClO3 and zeolitic imidazolate framework-
12 (ZIF-12). Pyrolysis of ZIF-12 with different concentrations of KClO3 leads
to embedded Co and Co3O4 nanoparticles in a conductive amorphous carbon
network. The impact of salt concentration on the morphology and
electrochemical performance of these composites was investigated for
electrochemical sensor applications. By employing a straightforward and
efficient technique, Co/Co3O4 heterostructures were successfully synthesized
in N-doped porous amorphous carbon. The Co/Co3O4 carbon hetero-
structures were optimized by varying the salt concentration, resulting in a
significant electrochemical sensor performance for detecting ALC in both bulk
and biological fluids. The sensor demonstrates excellent sensitivity (62.97
nmol/L) and selectivity toward ALC, with a wide linear range (0.22 μM) and a low detection limit (18.89 nM). Furthermore, it
displays remarkable stability and reproducibility, positioning it as a strong contender for practical use in pharmaceutical analysis and
biomedical research. This study presents a significant advancement in electrochemical sensing technology and underscores the
potential of Co/Co3O4 heterostructures in the development of high-performance sensors for detecting bioactive compounds in
complex matrices3O4 heterostructures were successfully synthesized
in N-doped porous amorphous carbon. The Co/Co3O4 carbon hetero-
structures were optimized by varying the salt concentration, resulting in a
significant electrochemical sensor performance for detecting ALC in both bulk
and biological fluids. The sensor demonstrates excellent sensitivity (62.97
nmol/L) and selectivity toward ALC, with a wide linear range (0.22 μM) and a low detection limit (18.89 nM). Furthermore, it
displays remarkable stability and reproducibility, positioning it as a strong contender for practical use in pharmaceutical analysis and
biomedical research. This study presents a significant advancement in electrochemical sensing technology and underscores the
potential of Co/Co3O4 heterostructures in the development of high-performance sensors for detecting bioactive compounds in
complex matrices