Akademik Veri Yönetim Sistemi
Hacettepe University Journal of the Faculty of Pharmacy, cilt.44, sa.1, ss.38-45, 2023 (Scopus)
The purpose of this study was to investigate the factors that required dose adjustments
of antimicrobial drugs in intensive care unit (ICU) patients and to identify
the drugs that required the most dose adjustments. The current prospective study
was conducted in the reanimation ICU with 26-bed capacity of a university-affiliated
hospital from September to December 2022. Two clinical pharmacists
on duty examined patients’ antimicrobial drug dosages daily. The acceptance
status of the recommendations and the patients’ demographic information were
recorded. The study involved 133 ICU patients, and antimicrobial drug recommendations
were made for 48 patients, 31 (64.6%) of whom were male. The
median (IQR) age of the 48 patients was 67 (54–77). The count of recommendations
was 94, and the acceptance rate was 100%. The recommendation rates
were as follows: 71.3% for renal function, 11.7% for presence of continuous
renal replacement therapy, 10.6% for indication, 4.3% for body weight, and 2.1%
for loading dose. The top 3 drugs for which recommendations were made the
most were colistin (21.3%), meropenem (18.1%), and piperacillin-tazobactam
(12.8%). The most troublesome drug was colistin, which is frequently used to
treat Acinetobacter pneumonia. Clinical pharmacist and physician collaboration
may help rationalize ICU antimicrobial drug use.