ILC3 deficiency and generalized ILC abnormalities in DOCK8-deficient patients

ÖZEN A. O., ÖZEN A. O., ÖZEN A. O., ÖZEN A. O., ÖZEN A. O., ÖZEN A. O., ...Daha Fazla

ALLERGY, cilt.75, sa.4, ss.921-933, 2020 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 75 Sayı: 4
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1111/all.14081
  • Dergi Adı: ALLERGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Agricultural & Environmental Science Database, BIOSIS, CAB Abstracts, EMBASE, Food Science & Technology Abstracts, MEDLINE, Veterinary Science Database
  • Sayfa Sayıları: ss.921-933
  • İnönü Üniversitesi Adresli: Hayır

Özet

BackgroundDedicator of cytokinesis 8 (DOCK8) deficiency is the main cause of the autosomal recessive hyper-IgE syndrome (HIES). We previously reported the selective loss of group 3 innate lymphoid cell (ILC) number and function in a Dock8-deficient mouse model. In this study, we sought to test whether DOCK8 is required for the function and maintenance of ILC subsets in humans.