Effects of Rifaximin on Bacterial Translocation in Thioacetamide-Induced Liver Injury in Rats

HARPUTLUOĞLU M. M. M., Demirel U., GÜL M., TEMEL I., GURSOY S., SELÇUK E. B., ...Daha Fazla

INFLAMMATION, cilt.35, sa.4, ss.1512-1517, 2012 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 35 Sayı: 4
  • Basım Tarihi: 2012
  • Doi Numarası: 10.1007/s10753-012-9465-2
  • Dergi Adı: INFLAMMATION
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1512-1517
  • Anahtar Kelimeler: rifaximin, bacterial translocation, thioacetamide, liver injury, INTESTINAL DECONTAMINATION, OXIDATIVE STRESS, HEPATIC-FAILURE, CIRRHOTIC RATS, ENDOTOXEMIA, OVERGROWTH, MECHANISMS, MELATONIN, PROTECTS, DAMAGE
  • İnönü Üniversitesi Adresli: Evet

Özet

Intestinal bacterial overgrowth (IBO) and increased mucosal permeability are suggested to increase bacterial translocation (BT) in liver injury. Rifaximin (RIF) is a minimally absorbed oral antimicrobial agent that restores gut microflora imbalance. The aim of the present study was to investigate the effects of RIF on BT frequency in thioacetamide (TAA)-induced liver injury. Group 1 was the control. In group 2 (TAA), rats received TAA daily for 3 days. In group 3 (TAA + RIF), RIF was commenced on the same day as the first dose of TAA. In group 4 (RIF), rats received only RIF. Ileal aspirate Escherichia coli counts were significantly lower in the TAA + RIF group than in TAA group. There was no difference in BT frequency between the TAA and TAA + RIF groups. Our results suggest that factors such as intestinal barrier dysfunction and impaired host immune shield, apart from IBO, play an important role in BT in this model.