Investigation into the protective effects of Naringenin in phthalates-induced reproductive damage

TAŞLIDERE A., Turkmen N. B., Ciftci O., AYDIN M.

EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES, vol.26, no.10, pp.3419-3429, 2022 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 26 Issue: 10
  • Publication Date: 2022
  • Journal Name: EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE, Directory of Open Access Journals
  • Page Numbers: pp.3419-3429
  • Keywords: Di-n-butyl phthalate, Naringenin, Oxidative stress, Spermiotoxicity, Testicular damage, N-BUTYL PHTHALATE, IN-UTERO EXPOSURE, DIBUTYL PHTHALATE, DI(N-BUTYL) PHTHALATE, LIPID PEROXIDES, TOXICITY, RATS, METABOLITES, CISPLATIN, ASSAY
  • Inonu University Affiliated: Yes

Abstract

OBJECTIVE: Di-n-butyl phthalate (DBP) is a ubiquitous environmental pollutant, extensively used as a plasticizer in many products, including plastics. cosmetics. and medical devices. Naringenin (NAR) is a flavonoid belonging to the flavanones subclass. It is widely distributed in several citrus fruits, bergamot, tomatoes, and other fruits. It is also found in its glycoside form (mainly naringin). Several biological activities have been ascribed to this phytochemical: antioxidant, antitumor, antiviral, antibacterial, anti-inflammatory, antiadipogenic, and ca rdioprotective effects. This study hypothesized that phthalates' possible reproductive damage mechanism is oxidative attack, and naringenin could have a protective effect against radical forms in the body through its antioxidant properties.