Effects of cyanocobalamin on immunity in patients with pernicious anemia
MEDICAL PRINCIPLES AND PRACTICE, vol.17, no.2, pp.131-135, 2008 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 17 Issue: 2
- Publication Date: 2008
- Doi Number: 10.1159/000112967
- Journal Name: MEDICAL PRINCIPLES AND PRACTICE
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.131-135
- Keywords: pernicious anemia, vitamin B-12, immunity, natural killer cells, CD4/CD8 ratio, VITAMIN B-12-DEFICIENT RATS, LYMPHOCYTE SUBPOPULATIONS, MEGALOBLASTIC-ANEMIA, CELL-ACTIVITY, RESTORATION, METHYL-B12, THERAPY
- Inonu University Affiliated: Yes
Abstract
Objective: The aim of the study was to evaluate the role of vitamin B-12 in patients with pernicious anemia. Materials and Methods: This study was conducted prospectively at the Turgut Ozal Medical Center, Department of Hematology, between April and November 2002. Absolute numbers and ratio of the surface antigens of T and B lymphocyte subgroups, CD4/CD8 ratio were calculated in order to evaluate changes in leukocyte and lymphocyte numbers; natural killer (NK) cell count, serum C3, C4, and levels of immunoglobulins G, A, and M were also measured to evaluate vitamin B-12 effect on immunity. Values obtained before treatment with cyanocobalamin were compared with those found during peak reticulocyte count. Results: In vitamin B-12-deficient patients, absolute numbers of CD4+ and especially CD8+ lymphocytes were found to be decreased; CD4/CD8 ratio increased, and NK cell activity was depressed. After cyanocobalamin treatment, absolute numbers and percentage of lymphocyte subgroups were elevated. Increased CD4/CD8 ratio and depressed NK cell activity were restored and levels of C3, C4, and immunoglobulins were elevated. Conclusion: These findings suggest that vitamin B-12 has important immunomodulatory effects on cellular immunity, and abnormalities in the immune system in pernicious anemia are restored by vitamin B-12 replacement therapy. Copyright (C) 2008 S. Karger AG, Basel.