Antimicrobial activity, inhibition of biofilm formation, and molecular docking study of novel Ag-NHC complexes

ŞAHİN N., Ustun E., TUTAR U., ÇELİK C., GÜRBÜZ N., ÖZDEMİR İ.

JOURNAL OF ORGANOMETALLIC CHEMISTRY, cilt.954, 2021 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 954
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1016/j.jorganchem.2021.122082
  • Dergi Adı: JOURNAL OF ORGANOMETALLIC CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Chemical Abstracts Core, Chimica, Compendex, Index Chemicus (IC)
  • Anahtar Kelimeler: N-heterocyclic carbene, Benzimidazolium salt, Antimicrobial activity, Biofilm activity, Molecular docking, HETEROCYCLIC CARBENE COMPLEXES, THEORETICAL-ANALYSIS, MALATE SYNTHASE, MECHANISM, AG(I)
  • İnönü Üniversitesi Adresli: Evet

Özet

In this study, we reported the synthesis of a new series of Silver(I)-N-heterocyclic carbene complexes which were obtained from the corresponding new N-heterocyclic carbene (NHC) precursors. All new compounds were characterized by elemental analysis, FT-IR, LC-MS, H-1 NMR, and C-13{H-1} NMR spectroscopy. These new N-heterocyclic carbene precursors and Ag(I)-NHC complexes were evaluated for their antibacterial, antifungal, and antibiofilm activities. The biological activities of synthesized products were compared with standard drugs. All compounds have moderate antibacterial and antibiofilm activities. In particular, while compound 2a was found to be the best inhibitor of E. coli biofilms, while compound 2d inhibited C. albicans biofilm at the highest rate. All the compounds were also analyzed by molecular docking methods with the certain target molecules. (C) 2021 Elsevier B.V. All rights reserved.