The attenuation of vasospasm by using a SOD mimetic after experimental subarachnoidal haemorrhage in rats


ALADAG M., TURKOZ Y. , SAHNA E., Parlakpinar H. , GUL M.

ACTA NEUROCHIRURGICA, cilt.145, ss.673-677, 2003 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 145 Konu: 8
  • Basım Tarihi: 2003
  • Doi Numarası: 10.1007/s00701-003-0052-z
  • Dergi Adı: ACTA NEUROCHIRURGICA
  • Sayfa Sayıları: ss.673-677

Özet

Background. Delayed cerebral vasoconstriction and brain ischemia, are critical problems in the management of a patient affected by rupture of an intracranial aneurysm. Overexpression of Cu-Zn superoxide dismutase (Cu-Zn SOD) can reduce the extent of cerebral vasospasm. We, therefore investigated if vasospasm, can be prevented by a novel, stable, and cell permeable SOD mimetic, MnTBAP [Mn(III) tetrakis (4-benzoic acid) porphyrin] which permeates the biological membranes and scavenges superoxide anions and peroxynitrite.