Effects of valproate and carbamazepine on serum levels of homocysteine, vitamin B12, and folic acid

Karabiber H., Sommezgoz E., Ozerol E., Yakinci C., OTLU B., Yologlu S.

BRAIN & DEVELOPMENT, cilt.25, sa.2, ss.113-115, 2003 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 25 Sayı: 2
  • Basım Tarihi: 2003
  • Doi Numarası: 10.1016/s0387-7604(02)00163-8
  • Dergi Adı: BRAIN & DEVELOPMENT
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.113-115
  • Anahtar Kelimeler: homocysteine, sodium valproate, carbamazepine, folic acid, vitamin B12, EPILEPTIC PATIENTS, HYPERHOMOCYSTEINEMIA, ANTICONVULSANTS, DISEASE, RISK
  • İnönü Üniversitesi Adresli: Evet

Özet

Homocysteine (HMC) is a sulfur containing amino acid, which plays a role in methionine metabolism. Folic acid (FA) and vitamin B12 (B12) are essential for remethylization of HMC to methionine. HMC level increases in the deficiency of these vitamins. Hyperhomocysteinemia causes vascular endothelial damage, which causes atherosclerosis. The aim of this study is to investigate the effect of valproate (VA) and carbamazepine (CBZ) on the serum levels of HMC, B12, and FA.