Effects of valproate and carbamazepine on serum levels of homocysteine, vitamin B12, and folic acid


Karabiber H., Sommezgoz E., Ozerol E., Yakinci C., OTLU B. , Yologlu S.

BRAIN & DEVELOPMENT, cilt.25, ss.113-115, 2003 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 25 Konu: 2
  • Basım Tarihi: 2003
  • Doi Numarası: 10.1016/s0387-7604(02)00163-8
  • Dergi Adı: BRAIN & DEVELOPMENT
  • Sayfa Sayıları: ss.113-115

Özet

Homocysteine (HMC) is a sulfur containing amino acid, which plays a role in methionine metabolism. Folic acid (FA) and vitamin B12 (B12) are essential for remethylization of HMC to methionine. HMC level increases in the deficiency of these vitamins. Hyperhomocysteinemia causes vascular endothelial damage, which causes atherosclerosis. The aim of this study is to investigate the effect of valproate (VA) and carbamazepine (CBZ) on the serum levels of HMC, B12, and FA.