Effects of valproate and carbamazepine on serum levels of homocysteine, vitamin B12, and folic acid
BRAIN & DEVELOPMENT, vol.25, no.2, pp.113-115, 2003 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 25 Issue: 2
- Publication Date: 2003
- Doi Number: 10.1016/s0387-7604(02)00163-8
- Journal Name: BRAIN & DEVELOPMENT
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.113-115
- Keywords: homocysteine, sodium valproate, carbamazepine, folic acid, vitamin B12, EPILEPTIC PATIENTS, HYPERHOMOCYSTEINEMIA, ANTICONVULSANTS, DISEASE, RISK
- Inonu University Affiliated: Yes
Abstract
Homocysteine (HMC) is a sulfur containing amino acid, which plays a role in methionine metabolism. Folic acid (FA) and vitamin B12 (B12) are essential for remethylization of HMC to methionine. HMC level increases in the deficiency of these vitamins. Hyperhomocysteinemia causes vascular endothelial damage, which causes atherosclerosis. The aim of this study is to investigate the effect of valproate (VA) and carbamazepine (CBZ) on the serum levels of HMC, B12, and FA.