Cytoprotective effects of molsidomine against methotrexate-induced hepatotoxicity: an experimental rat study
DRUG DESIGN DEVELOPMENT AND THERAPY, cilt.13, ss.13-21, 2019 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 13
- Basım Tarihi: 2019
- Doi Numarası: 10.2147/dddt.s181550
- Dergi Adı: DRUG DESIGN DEVELOPMENT AND THERAPY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.13-21
- Anahtar Kelimeler: methotrexate, molsidomine, hepatotoxicity, hepatic fibrosis, NITRIC-OXIDE, TRANSIENT ELASTOGRAPHY, LIVER FIBROSIS, BETA-GLUCAN, INJURY, NEPHROTOXICITY, REPERFUSION, PSORIASIS, APOPTOSIS, DISEASE
- İnönü Üniversitesi Adresli: Evet
Özet
Introduction and aim: Methotrexate (Mtx) is an antineoplastic and immunosuppressive drug that may cause hepatotoxicity, whereas molsidomine (Mol) is a vasodilating and antioxidant agent. This study aimed to investigate the potential protective effects of Mol in Mtx-induced liver toxicity in rats.