Copy For Citation
ŞAMDANCI E., Huz M., ÖZHAN O., TANBEK K., PAMUKÇU E., AKATLI A. N., ...More
DRUG DESIGN DEVELOPMENT AND THERAPY, vol.13, pp.13-21, 2019 (SCI-Expanded)
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Publication Type:
Article / Article
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Volume:
13
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Publication Date:
2019
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Doi Number:
10.2147/dddt.s181550
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Journal Name:
DRUG DESIGN DEVELOPMENT AND THERAPY
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Journal Indexes:
Science Citation Index Expanded (SCI-EXPANDED), Scopus
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Page Numbers:
pp.13-21
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Keywords:
methotrexate, molsidomine, hepatotoxicity, hepatic fibrosis, NITRIC-OXIDE, TRANSIENT ELASTOGRAPHY, LIVER FIBROSIS, BETA-GLUCAN, INJURY, NEPHROTOXICITY, REPERFUSION, PSORIASIS, APOPTOSIS, DISEASE
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Inonu University Affiliated:
Yes
Abstract
Introduction and aim: Methotrexate (Mtx) is an antineoplastic and immunosuppressive drug that may cause hepatotoxicity, whereas molsidomine (Mol) is a vasodilating and antioxidant agent. This study aimed to investigate the potential protective effects of Mol in Mtx-induced liver toxicity in rats.