Cytoprotective effects of molsidomine against methotrexate-induced hepatotoxicity: an experimental rat study

ŞAMDANCI E. , Huz M., ÖZHAN O. , TANBEK K. , PAMUKÇU E., AKATLI A. N. , ...More

DRUG DESIGN DEVELOPMENT AND THERAPY, vol.13, pp.13-21, 2019 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 13
  • Publication Date: 2019
  • Doi Number: 10.2147/dddt.s181550
  • Title of Journal : DRUG DESIGN DEVELOPMENT AND THERAPY
  • Page Numbers: pp.13-21
  • Keywords: methotrexate, molsidomine, hepatotoxicity, hepatic fibrosis, NITRIC-OXIDE, TRANSIENT ELASTOGRAPHY, LIVER FIBROSIS, BETA-GLUCAN, INJURY, NEPHROTOXICITY, REPERFUSION, PSORIASIS, APOPTOSIS, DISEASE

Abstract

Introduction and aim: Methotrexate (Mtx) is an antineoplastic and immunosuppressive drug that may cause hepatotoxicity, whereas molsidomine (Mol) is a vasodilating and antioxidant agent. This study aimed to investigate the potential protective effects of Mol in Mtx-induced liver toxicity in rats.