Cytoprotective effects of molsidomine against methotrexate-induced hepatotoxicity: an experimental rat study

ŞAMDANCI E., Huz M., ÖZHAN O., TANBEK K., PAMUKÇU E., AKATLI A. N., ...More

DRUG DESIGN DEVELOPMENT AND THERAPY, vol.13, pp.13-21, 2019 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 13
  • Publication Date: 2019
  • Doi Number: 10.2147/dddt.s181550
  • Journal Name: DRUG DESIGN DEVELOPMENT AND THERAPY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.13-21
  • Keywords: methotrexate, molsidomine, hepatotoxicity, hepatic fibrosis, NITRIC-OXIDE, TRANSIENT ELASTOGRAPHY, LIVER FIBROSIS, BETA-GLUCAN, INJURY, NEPHROTOXICITY, REPERFUSION, PSORIASIS, APOPTOSIS, DISEASE
  • Inonu University Affiliated: Yes

Abstract

Introduction and aim: Methotrexate (Mtx) is an antineoplastic and immunosuppressive drug that may cause hepatotoxicity, whereas molsidomine (Mol) is a vasodilating and antioxidant agent. This study aimed to investigate the potential protective effects of Mol in Mtx-induced liver toxicity in rats.