Cytoprotective effects of molsidomine against methotrexate-induced hepatotoxicity: an experimental rat study

ŞAMDANCI E., Huz M., ÖZHAN O., TANBEK K., PAMUKÇU E., AKATLI A. N., ...Daha Fazla

DRUG DESIGN DEVELOPMENT AND THERAPY, cilt.13, ss.13-21, 2019 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 13
  • Basım Tarihi: 2019
  • Doi Numarası: 10.2147/dddt.s181550
  • Dergi Adı: DRUG DESIGN DEVELOPMENT AND THERAPY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.13-21
  • Anahtar Kelimeler: methotrexate, molsidomine, hepatotoxicity, hepatic fibrosis, NITRIC-OXIDE, TRANSIENT ELASTOGRAPHY, LIVER FIBROSIS, BETA-GLUCAN, INJURY, NEPHROTOXICITY, REPERFUSION, PSORIASIS, APOPTOSIS, DISEASE
  • İnönü Üniversitesi Adresli: Evet

Özet

Introduction and aim: Methotrexate (Mtx) is an antineoplastic and immunosuppressive drug that may cause hepatotoxicity, whereas molsidomine (Mol) is a vasodilating and antioxidant agent. This study aimed to investigate the potential protective effects of Mol in Mtx-induced liver toxicity in rats.