Cytoprotective effects of molsidomine against methotrexate-induced hepatotoxicity: an experimental rat study
DRUG DESIGN DEVELOPMENT AND THERAPY, vol.13, pp.13-21, 2019 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 13
- Publication Date: 2019
- Doi Number: 10.2147/dddt.s181550
- Journal Name: DRUG DESIGN DEVELOPMENT AND THERAPY
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.13-21
- Keywords: methotrexate, molsidomine, hepatotoxicity, hepatic fibrosis, NITRIC-OXIDE, TRANSIENT ELASTOGRAPHY, LIVER FIBROSIS, BETA-GLUCAN, INJURY, NEPHROTOXICITY, REPERFUSION, PSORIASIS, APOPTOSIS, DISEASE
- Inonu University Affiliated: Yes
Abstract
Introduction and aim: Methotrexate (Mtx) is an antineoplastic and immunosuppressive drug that may cause hepatotoxicity, whereas molsidomine (Mol) is a vasodilating and antioxidant agent. This study aimed to investigate the potential protective effects of Mol in Mtx-induced liver toxicity in rats.