Cytoprotective effects of molsidomine against methotrexate-induced hepatotoxicity: an experimental rat study


ŞAMDANCI E. , Huz M., ÖZHAN O. , TANBEK K. , PAMUKÇU E., AKATLI A. N. , ...Daha Fazla

DRUG DESIGN DEVELOPMENT AND THERAPY, cilt.13, ss.13-21, 2019 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 13
  • Basım Tarihi: 2019
  • Doi Numarası: 10.2147/dddt.s181550
  • Dergi Adı: DRUG DESIGN DEVELOPMENT AND THERAPY
  • Sayfa Sayıları: ss.13-21

Özet

Introduction and aim: Methotrexate (Mtx) is an antineoplastic and immunosuppressive drug that may cause hepatotoxicity, whereas molsidomine (Mol) is a vasodilating and antioxidant agent. This study aimed to investigate the potential protective effects of Mol in Mtx-induced liver toxicity in rats.