Silver(I) N-heterocyclic carbene complexes: Synthesis, characterization and cytotoxic properties

GÜRBÜZ N., Kaloğlu N., Kızrak Ü., ÖZDEMİR İ., Türkmen N. B., Çiftçi O., ...Daha Fazla

JOURNAL OF ORGANOMETALLIC CHEMISTRY, cilt.923, 2020 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 923
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1016/j.jorganchem.2020.121434
  • Dergi Adı: JOURNAL OF ORGANOMETALLIC CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Chimica, Compendex
  • Anahtar Kelimeler: N-heterocyclic carbene, Benzimidazolium salts, Sultone, Silver-NHC complexes, Antitumor activity, CARBENE-SILVER(I) ACETATE COMPLEXES, CROSS-COUPLING REACTIONS, ANTICANCER ACTIVITY, PRECURSORS, CHEMISTRY, CATALYSTS, AU(I), NMR
  • İnönü Üniversitesi Adresli: Evet

Özet

In this study, sulfonate functionalized N-heterocyclic carbene ligand precursors were obtained from the compounds 1-alkylbenzimidazole, 1,3-propane sultone, and 1,4-butane sultone. These NHC ligand precursors were metallated with Ag2O on moderate conditions to give novel silver-NHC complexes. All new compounds were characterized by by H-1 NMR, C-13 NMR, FT-IR and elemental analysis techniques. The cytotoxic properties of the silver(I) complexes have been assessed in various human cancer lines, including cisplatin-sensitive and resistant cells. IC50 values of these four complexes were determined by the MTT based assay on three human cell lines brain (SHSY5Y) and liver (HEP3B). These silver N-heterocyclic carbene complexes have been highlighted metal-based cancer therapeutic agents with unique structures and functions. These strategies provide exciting opportunities for discovering new types of metallodrugs. (C) 2020 Elsevier B.V. All rights reserved.