Cytoprotective effects of amifostine, ascorbic acid and N-acetylcysteine against methotrexate-induced hepatotoxicity in rats

Akbulut, AHMET; Elbe, Hulya; Eris, Cengiz; Doğan, Zümrüt; Toprak, Gulten; Otan, EMRAH; Erdemli, MEHMET; Turkoz, YUSUF

doi:10.3748/wjg.v20.i29.10158

Cytoprotective effects of amifostine, ascorbic acid and N-acetylcysteine against methotrexate-induced hepatotoxicity in rats

Akbulut S., Elbe H., Eris C., Doğan Z., Toprak G., Otan E., ...Daha Fazla

WORLD JOURNAL OF GASTROENTEROLOGY, cilt.20, sa.29, ss.10158-10165, 2014 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 20 Sayı: 29
Basım Tarihi: 2014
Doi Numarası: 10.3748/wjg.v20.i29.10158
Dergi Adı: WORLD JOURNAL OF GASTROENTEROLOGY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.10158-10165
Anahtar Kelimeler: Methotrexate, Amifostine, N-acetyl cysteine, Ascorbic acid, Hepatotoxicity, Oxidative stress, OXIDATIVE STRESS, VITAMIN-C, TOXICITY
İnönü Üniversitesi Adresli: Evet

Özet

AIM: To investigate the potential role of oxidative stress and the possible therapeutic effects of N-acetyl cysteine (NAC), amifostine (AMF) and ascorbic acid (ASC) in methotrexate (MTX)-induced hepatotoxicity.