Cytoprotective effects of amifostine, ascorbic acid and N-acetylcysteine against methotrexate-induced hepatotoxicity in rats

Akbulut, AHMET; Elbe, Hulya; Eris, Cengiz; Doğan, Zümrüt; Toprak, Gulten; Otan, EMRAH; Erdemli, MEHMET; Turkoz, YUSUF

doi:10.3748/wjg.v20.i29.10158

Cytoprotective effects of amifostine, ascorbic acid and N-acetylcysteine against methotrexate-induced hepatotoxicity in rats

Atıf İçin Kopyala

Akbulut S. , Elbe H., Eris C., Doğan Z., Toprak G., Otan E. , ...Daha Fazla

WORLD JOURNAL OF GASTROENTEROLOGY, cilt.20, ss.10158-10165, 2014 (SCI İndekslerine Giren Dergi)

Cilt numarası: 20
Basım Tarihi: 2014
Doi Numarası: 10.3748/wjg.v20.i29.10158
Dergi Adı: WORLD JOURNAL OF GASTROENTEROLOGY
Sayfa Sayıları: ss.10158-10165

Özet

AIM: To investigate the potential role of oxidative stress and the possible therapeutic effects of N-acetyl cysteine (NAC), amifostine (AMF) and ascorbic acid (ASC) in methotrexate (MTX)-induced hepatotoxicity.