Cytoprotective effects of amifostine, ascorbic acid and N-acetylcysteine against methotrexate-induced hepatotoxicity in rats

Akbulut S., Elbe H., Eris C., Doğan Z., Toprak G., Otan E., ...Daha Fazla

WORLD JOURNAL OF GASTROENTEROLOGY, cilt.20, sa.29, ss.10158-10165, 2014 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 20 Sayı: 29
  • Basım Tarihi: 2014
  • Doi Numarası: 10.3748/wjg.v20.i29.10158
  • Dergi Adı: WORLD JOURNAL OF GASTROENTEROLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.10158-10165
  • Anahtar Kelimeler: Methotrexate, Amifostine, N-acetyl cysteine, Ascorbic acid, Hepatotoxicity, Oxidative stress, OXIDATIVE STRESS, VITAMIN-C, TOXICITY
  • İnönü Üniversitesi Adresli: Evet

Özet

AIM: To investigate the potential role of oxidative stress and the possible therapeutic effects of N-acetyl cysteine (NAC), amifostine (AMF) and ascorbic acid (ASC) in methotrexate (MTX)-induced hepatotoxicity.