Akademik Veri Yönetim Sistemi
8. INTERNATIONAL CONFERENCE ON ADVANCES IN NATURAL AND APPLIED SCIENCES , Antalya, Türkiye, 28 - 31 Ekim 2025, ss.169, (Özet Bildiri)
N-heterocyclic carbenes (NHCs) have received significant attention as ligands, particularly over the last three decades. They are among the most interesting ligands in organic, organometallic, and catalytic chemistry [1]. The biological activities of various metal complexes of these ligands were known. In 2006, Organ and colleagues synthesized a new stable palladium(II) complex containing an NHC and a 3-chloropyridine ligand [2]. These new complexes were termed PEPPSI (Pyridine Enhanced Precatalyst Preparation, Stabilization, and Initiation)-type complexes. Although initially used as catalysts [2], PEPPSI complexes have recently been identified as multitarget enzyme inhibitors [3]. In conclusion, herein, the PEPPSI-type Pd(II)NHC complexes with trifluoromethyl containing NHC liganded were synthesized. All complexes were characterized using ¹H NMR, ¹³C NMR, and FTIR spectroscopic techniques. These complexes exhibited active inhibitory properties against carbonıcanhydrase I(hCAI), carbonıcanhydrase II(hCAII), acetylcholinesterase (AChE), and butyrylcholinesterase (BChE).