Daily cortisol awakening response and menstrual symptoms in young females

Ozgocer T., UÇAR C., YILDIZ S.

STRESS AND HEALTH, cilt.38, sa.1, ss.57-68, 2022 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 38 Sayı: 1
  • Basım Tarihi: 2022
  • Doi Numarası: 10.1002/smi.3074
  • Dergi Adı: STRESS AND HEALTH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Social Sciences Citation Index (SSCI), Scopus, Academic Search Premier, BIOSIS, CINAHL, EMBASE, MEDLINE, Psycinfo, SportDiscus
  • Sayfa Sayıları: ss.57-68
  • Anahtar Kelimeler: cortisol awakening response, menstrual cycle, oestradiol, progesterone, pain, sleep, premenstrual symptoms, SALIVARY CORTISOL, INTERINDIVIDUAL DIFFERENCES, PREMENSTRUAL-SYNDROME, STATE VARIATION, PROGESTERONE, ESTRADIOL, CYCLE, WOMEN, TIME, ASSOCIATION
  • İnönü Üniversitesi Adresli: Evet

Özet

Menstrual symptoms include some rhythmical changes and stress perception but women differ in duration and severity of these symptoms. It is not known whether these differences are associated with cortisol awakening response (CAR). The aim of the current study was to follow young women daily for the CAR and menstrual parameters throughout the whole menstrual cycle. Healthy and regularly cycling young women (n = 16, 17 to 31-year-old) participated in the current study. The daily records of severity of problems (DRSP) was filled in daily by the participants. CAR was also assessed daily form the salivary samples collected at a 0-, 15-, 30- and 60-min post-awakening. In terms of daily awakening cortisol profiles, women had either 2-20 (n = 3), or 20-200 (n = 8) or 200-2000 (n = 5) ng/ml cortisol according to the median levels throughout their cycle. CAR was weakly and negatively correlated with DRSP scores but strongly and positively with oestradiol (R-2 = 0.300; p = 0.000) and progesterone (R-2 = 0.490; p = 0.000) concentrations. Individuals with higher oestradiol and progesterone concentrations did not have high DRSP scores. In conclusion, CAR had a very high between-subject difference but had a low within-subject difference throughout the days of menstrual cycle, suggesting that CAR is a relatively stable personal trait. Moreover, the interplay between cortisol, progesterone and oestradiol appears to be important for the severity of menstrual symptoms.