Can T2 blackout effect be a marker of iron accumulation in brains of multiple sclerosis patients?

ERBAY M. F. , KAMIŞLI Ö., Karatoprak N. B.

BRITISH JOURNAL OF RADIOLOGY, vol.93, no.1113, 2020 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 93 Issue: 1113
  • Publication Date: 2020
  • Doi Number: 10.1259/bjr.20200552
  • Journal Indexes: Science Citation Index Expanded, Scopus, Academic Search Premier, CAB Abstracts, CINAHL, EMBASE, MEDLINE, Veterinary Science Database


Objective : T2 blackout (TBO) effect, which is a common finding in the brains of multiple sclerosis (MS) patients and older population that are imaged for other reasons on diffusion weighted imagings (DWI) and apparent diffusion coefficient (ADC) map show the existence of paramagnetic materials in the tissue. Because iron is known to accumulate in especially deep gray matter (DGM) structures in MS brains, we aimed to investigate the relationship between TBO and clinico-radiological parameters that may be iron-related in MS.