Synthesis and characterization of novel phosphoramidates containing benzimidazole moiety

Yilmaz U., KÜÇÜKBAY H.

PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, vol.191, no.1, pp.140-143, 2016 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 191 Issue: 1
  • Publication Date: 2016
  • Doi Number: 10.1080/10426507.2015.1067209
  • Journal Name: PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.140-143
  • Keywords: Benzimidazole, diphenyl chlorophosphate, phosphoramidates, phosphonate, argon atmosphere, ester of phosphonic acid, ION-COORDINATING PROPERTIES, ISOMERIC EQUILIBRIA, ACID, PHOSPHONATE, INHIBITORS, PRODRUGS, DESIGN, QUANTIFICATION, DERIVATIVES, COPOLYMERS
  • Inonu University Affiliated: Yes

Abstract

Novel heterocyclic phosphoramidates were synthesized by a nucleophilic substitution reaction of 2-substitutedbenzimidazoles and diphenyl chlorophosphate (ClPO3Ph2) in the presence of potassium hydroxide (KOH) under an argon atmosphere. The structures of the phosphoramidates were characterized by NMR, IR, melting point, and elemental analysis.