Protective effect of leflunomide against oxidative intestinal injury in a rodent model of sepsis

Ozturk E., Surucu M., Karaman A., ŞAMDANCI E., Fadillioglu E.

JOURNAL OF SURGICAL RESEARCH, cilt.187, sa.2, ss.610-615, 2014 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 187 Sayı: 2
  • Basım Tarihi: 2014
  • Doi Numarası: 10.1016/j.jss.2013.11.005
  • Dergi Adı: JOURNAL OF SURGICAL RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.610-615
  • Anahtar Kelimeler: Sepsis, Leflunomide, Oxidative stress, NITRIC-OXIDE, PROTEIN-KINASE
  • İnönü Üniversitesi Adresli: Evet

Özet

Background: Sepsis is defined as an uncontrolled inflammatory response in a host. The process may lead to severe sepsis, multisystem organ failure and even death. Leflunomide has important immunomodulatory and anti-inflammatory effects, which may mitigate host response to bacterial translocation. The goal of our study was to measure the effects leflunomide administration had on a variety of biochemical markers upregulated in systemic inflammatory response syndrome, sepsis, and multiple organ failure syndrome.