Protective effect of leflunomide against oxidative intestinal injury in a rodent model of sepsis


Ozturk E., Surucu M., Karaman A., ŞAMDANCI E. , Fadillioglu E.

JOURNAL OF SURGICAL RESEARCH, cilt.187, ss.610-615, 2014 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 187 Konu: 2
  • Basım Tarihi: 2014
  • Doi Numarası: 10.1016/j.jss.2013.11.005
  • Dergi Adı: JOURNAL OF SURGICAL RESEARCH
  • Sayfa Sayıları: ss.610-615

Özet

Background: Sepsis is defined as an uncontrolled inflammatory response in a host. The process may lead to severe sepsis, multisystem organ failure and even death. Leflunomide has important immunomodulatory and anti-inflammatory effects, which may mitigate host response to bacterial translocation. The goal of our study was to measure the effects leflunomide administration had on a variety of biochemical markers upregulated in systemic inflammatory response syndrome, sepsis, and multiple organ failure syndrome.