Novel N-Heterocyclic Carbene Silver(I) Complexes: Synthesis, Structural Characterization, Antimicrobial and Cytotoxicity Potential Studies

Slimani I., Chakchouk-Mtibaa A., Mellouli L., Mansour L., ÖZDEMİR İ., GÜRBÜZ N., ...Daha Fazla

JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY, cilt.31, sa.10, ss.2058-2070, 2020 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 31 Sayı: 10
  • Basım Tarihi: 2020
  • Doi Numarası: 10.21577/0103-5053.20200107
  • Dergi Adı: JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Analytical Abstracts, CAB Abstracts, Chemical Abstracts Core, Veterinary Science Database, Directory of Open Access Journals
  • Sayfa Sayıları: ss.2058-2070
  • Anahtar Kelimeler: N-heterocyclic carbene, benzimidazolium salts, silver(I)-NHC complexes, antimicrobial and antitumor activities, CRYSTAL-STRUCTURES, TOXICITY, GOLD(I), GROWTH, ASSAY
  • İnönü Üniversitesi Adresli: Evet

Özet

In this study, a series of unsymmetrical N,N-disubstituted benzimidazolium salts were synthesized as N-heterocyclic carbene (NHC) (2a-2j) and their Ag-I complexes. Their structures were characterized by elemental analyses, H-1 and C-13 nuclear magnetic resonance (NMR) and infrared (IR) spectroscopy techniques. Further, both the salts and their silver(I)-NHC complexes have been evaluated for their potential antibacterial properties against a panel of bacterial strains namely, Micrococcus luteus, Listeria monocytogenes, Salmonella Typhimurium, Staphylococcus aureus and Pseudomonas aeruginosa. The results show that silver complexes are effective against Salmonella Typhimurium, Listeria monocytogenes, and Micrococcus luteus with moderate to high activity, and their minimum inhibitory concentrations ranging from 0.0034 to 1.26 mg mL(-1). In addition, the benzimidazoles salts 2a-2j and silver-NHC complexes 3a-3j were screened for their antitumor activity. Complex 3e exhibited the highest antitumor effect with half-maximal inhibitory concentration (IC50) value of 4.2 mu g mL(-1) against MCF-7.