Akademik Veri Yönetim Sistemi
CLINICAL AND EXPERIMENTAL ALLERGY, sa.53, ss.626-645, 2023 (SCI-Expanded, Scopus)
AbstractBackground: Although the skin prick test (SPT) is a reliable procedure to confirm IgE- dependent allergic sensitization in patients, the interpretation of the test is still per-formed manually, resulting in an error- prone procedure for the diagnosis of allergic diseases.Objective: To design and implement an innovative SPT evaluation framework using a low- cost, portable smartphone thermography, named Thermo-SPT, to significantly improve the accuracy and reliability of SPT outcomes.Methods: Thermographical images were captured every 60 s for a duration of 0 to 15 min using the FLIR One app, and then analysed with the FLIR Tool®. The defini-tion of ‘Skin Sensitization Region’ area was introduced to analyse the time- lapse ther-mal changes in skin reactions over several time periods during the SPT. The Allergic Sensitization Index (ASI) and Min–Max Scaler Index (MMS) formulae were also devel-oped to optimize the identification of the peak allergic response time point through the thermal assessment (TA) of allergic rhinitis patients.Results: In these experimental trials, a statistically significant increase in temperature was detected from the fifth minute of TA for all tested aeroallergens (all p values <.001). An increase was observed in the number of false-positive cases, where patients with clinical symptoms not consistent with SPT were evaluated as positive on TA assess-ment, specifically for patients diagnosed with Phleum pratense and Dermatophagoides pteronyssinus. Our proposed technique, the MMS, has demonstrated improved ac-curacy in identifying P. pratense and D. pteronyssinus compared with other SPT evalu-ation metrics, specifically starting from the fifth minute. For patients diagnosed with Cat epithelium, although not statistically significant initially, an increasing trend was determined in the results at the 15 min (ΔT (T15 − T0), p=.07; ASIT15, p<.001).Conclusions: This proposed SPT evaluation framework utilizing a low-cost, smartphone- based thermographical imaging technique can enhance the interpretability of allergic responses during the SPT, potentially reducing the need for extensive manual inter-pretation experience as standard SPTs.