Risperidone and ethyl pyruvate have protective effects against ketamine-induced cognitive impairments in mice

Kelle I., Eriman H., Erdinc M., Uyar E.

EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES, cilt.26, sa.5, ss.1708-1716, 2022 (SCI-Expanded, Scopus) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 26 Sayı: 5
  • Basım Tarihi: 2022
  • Dergi Adı: EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.1708-1716
  • Anahtar Kelimeler: Ethyl pyruvate, Risperidone, Ketamine, Schizophrenia, Cognitive symptoms, NMDA RECEPTOR ANTAGONISTS, NEURONAL CELL-DEATH, OXIDATIVE STRESS, RECOGNITION MEMORY, MODEL, SEROTONIN, DAMAGE, BRAIN, DOPAMINE-D-2, PERFORMANCE
  • İnönü Üniversitesi Adresli: Evet

Özet

OBJECTIVE: Ketamine, an N-methyl D-aspartic acid receptor antagonist drug, is reported to produce memory disruptions. The aim of this study was to investigate the protective effects of ethyl pyruvate (EP), a pyruvic acid derivative, and risperidone, an atypical anti-psychotic drug, against ketamine-induced cognitive disturbances.