Akademik Veri Yönetim Sistemi
EuroMedLab 2025 , Brussels, Belçika, 18 - 22 Mayıs 2025, cilt.63, ss.2130, (Özet Bildiri)
IS SUBCLINICAL INFLAMMATION PRESENT IN CHILDREN WITH IRON DEFICIENCY ANEMIA?
H.C. Katırcı 1, C. Mertoğlu 1 1Inonu University Medical Biochemistry
BACKGROUND-AIM Iron deficiency anemia (IDA) is commonly found in children and is associated with many cardiac, neurological and gastrointestinal disorders. In this study, hemogram parameters and subclinical inflammation in children with iron deficiency anemia were investigated.
METHODS Laboratory information system records were examined. The hemogram parameters and indices derived from them in children aged 0–18 years who were diagnosed with IDA(n=794 male, 695 female) in the 5 years (January 1, 2019–December 31, 2024) were compared with those of children diagnosed with general medical examination(n=797 male, 570 female). Neutrophil-to-lymphocyte ratio(NLR) was calculated as neutrophil/ lymphocyte, platelet-tolymphocyte ratio(PLR) as platelet/lymphocyte, and SII as systemic immune-inflammation index (platelet × neutrophil/ lymphocyte).
RESULTS We compared the IDA and the general medical examination group, listing the mean ± standard deviation values in this order, respectively. Age(5.96±5.05 years, 6.60±5.09, p<0.001) hemoglobin(11.7±1.75 g/dL, 12.8±1.56, p<0.001), hematocrit(36.8±4.50 %, 39.3±4.40, p<0.001), mean corpuscular volume(76.1±7.31 fL, 80.9±6.13, p<0.001), mean corpuscular hemoglobin(24.2±3.30 pg, 26.4±2.54, p<0.001), mean corpuscular hemoglobin concentration(31.7±2.01 g/ dL, 32.6±1.48, p<0.001 ) values of the IDA group were lower compared to the other group, while red cell distribution width–coefficient of variation value(15.1±2.86 %, 13.6±1.62, p<0.001) was higher. NLR, PLR and SII values were found to be similar in both groups.
CONCLUSIONS There is no subclinical inflammation in children with iron deficiency anemia. However, this issue should be clarified with more sensitive inflammation parameters in prospective studies.