Prevention of toxic effects of orally administered tartrazine by crocin in Wistar rats

Altinoz E., ERDEMLİ M. E., GÜL M., Erdemli Z., GÜL S., Turkoz Y.

TOXICOLOGICAL AND ENVIRONMENTAL CHEMISTRY, vol.103, no.2, pp.184-198, 2021 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 103 Issue: 2
  • Publication Date: 2021
  • Doi Number: 10.1080/02772248.2021.1942472
  • Journal Name: TOXICOLOGICAL AND ENVIRONMENTAL CHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aerospace Database, Aqualine, Aquatic Science & Fisheries Abstracts (ASFA), BIOSIS, Biotechnology Research Abstracts, CAB Abstracts, Chemical Abstracts Core, Communication Abstracts, Compendex, Environment Index, Food Science & Technology Abstracts, Geobase, Greenfile, Metadex, Pollution Abstracts, Veterinary Science Database, Civil Engineering Abstracts
  • Page Numbers: pp.184-198
  • Keywords: Tartrazine, crocin, oxidative stress, malondialdehyde, ileum, colon, OXIDATIVE STRESS, ISCHEMIA-REPERFUSION, SAFFRON EXTRACT, DYE TARTRAZINE, SATIVUS L., AZO-DYE, ANTIOXIDANT, PROTECTS, CONSTITUENTS, MEMORY
  • Inonu University Affiliated: Yes

Abstract

Tartrazine is used in the pharmaceutical, cosmetic, and food industries worldwide, despite its many toxic effects. The therapeutic effects of crocin (50mg/kg/day) against tartrazine-induced (500mg/kg/day) oxidative damage in ileum and colon tissues in rats have been investigated. Malondialdehyde and total oxidant status levels elevated by tartrazine within the ileum and colon tissues were reduced with crocin treatment, while tartrazine decreased antioxidative parameters (glutathione, total antioxidant status, superoxide dismutase, and catalase) were reverted. Tartrazine-induced histopathological changes of ileum and colon tissues were ameliorated following crocin treatment. In conclusion, Tartrazine consumption elicited tissue injury via lipid peroxidation, and crocin ameliorated oxidative injury by its antioxidant and free radical scavenger properties.