Akademik Veri Yönetim Sistemi
International Journal of Medicinal Plants and Natural Products, cilt.8, sa.2, ss.1-8, 2022 (Hakemli Dergi)
In this study, it was aimed to investigate the possible genoprotective effects of Plantago lanceolata (Plantago L.) plant extract, which has been various phytotherapeutic properties, especially wound healing, and Luteolin-7-B-D-glicoside (LUT-7G), one of the important components of the plant, on human lymphocytes and HEPG-2 cells. The genoprotective effects of Plantago L. extract (200 and 500 μg/ml) and LUT-7G (10, 20, 30 µM) on lymphocytes and HepG-2 cells with and without DNA damage were investigated using comet analysis. In the study, while DNA damage (% DNAT) increased only in the high concentration groups of plant extract and LUT-7G in lymphocyte cells, it increased in all groups in HEPG-2 cells. In the DNA damaged cells, comet parameters decreased at all concentrations in lymphocytes however it decreased at only plant groups and 10 µM LUT-7G group in HEPG-2 cells. Plantago L. extract and LUT-7G showed genotoxic effect at all concentrations in HEPG-2 cells and only in high concentrations in lymphocytes but test substances showed genoprotective properties by reducing genetically damaged cells. Thus, we can say that the Plantago L. and LUT-7G are antigenotoxic in healthy cells, and genotoxic in cancer cells, depending on the dose.