Caffeic acid phenethyl ester changes the indices of oxidative stress in serum of rats with renal ischaemia-reperfusion injury

Ozyurt H., Irmak M., Akyol O., Sogut S.

CELL BIOCHEMISTRY AND FUNCTION, cilt.19, ss.259-263, 2001 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 19 Konu: 4
  • Basım Tarihi: 2001
  • Doi Numarası: 10.1002/cbf.923
  • Sayfa Sayıları: ss.259-263


Oxygen-derived free radicals have been implicated in the pathogenesis of renal injury after ischaemia-reperfusion. Caffeic acid phencthyl ester (CAPE), an active component of propolis extract, exhibits antioxidant properties. To investigate whether treatment with either CAPE or alpha-tocopherol modifies the levels of the endogenous indices of oxidant stress, we examined their effects on an in vivo model of renal ischaemia-reperfusion injury in rats. CA-PE at 10 mu mol kg(-1) or alpha-tocopherol at 10 mg kg(-1) was administered intraperitoneally before reperfusion. Acute administration of both CAPE and alpha-tocopherol altered the indices of oxidative stress differently in renal ischaemia-reperfusion injury. Copyright (C) 2001 John Wiley & Sons, Ltd.