Inflammasome dysregulation in human gingival fibroblasts in response to periodontal pathogens

Aral K., Milward M. R., Cooper P. R.

ORAL DISEASES, cilt.28, sa.1, ss.216-224, 2022 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 28 Sayı: 1
  • Basım Tarihi: 2022
  • Doi Numarası: 10.1111/odi.13760
  • Dergi Adı: ORAL DISEASES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, CINAHL, EMBASE, MEDLINE, Veterinary Science Database
  • Sayfa Sayıları: ss.216-224
  • Anahtar Kelimeler: Fusobacterium nucleatum, gingival fibroblasts, inflammasome, interleukin-1 beta, periodontal disease, Porphyromonas gingivalis
  • İnönü Üniversitesi Adresli: Evet

Özet

Objective Uncontrolled production of Interleukin-1 beta (IL-1 beta), a major proinflammatory cytokine, is associated with tissue destruction in periodontal disease. IL-1 beta production is controlled by inflammasomes which are multiprotein regulatory complexes. The current study aimed to elucidate potential regulatory pathways by monitoring the effects of periodontal pathogens Fusobacterium nucleatum (Fn) and Porphyromonas gingivalis (Pg) on inflammasomes and their regulators in human gingival fibroblasts (HGFs) in vitro.