Chemistry, structure, and biological roles of Au-NHC complexes as TrxR inhibitors

KARAASLAN M. G., AKTAŞ A., GÜRSES C., GÖK Y., ATEŞ B.

BIOORGANIC CHEMISTRY, cilt.95, 2020 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 95
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1016/j.bioorg.2019.103552
  • Dergi Adı: BIOORGANIC CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, Biotechnology Research Abstracts, CAB Abstracts, Chimica, EMBASE, MEDLINE, Veterinary Science Database
  • Anahtar Kelimeler: Au-NHC complexes, Anticancer activity, TrxR inhibitors, Enzyme, HETEROCYCLIC CARBENE COMPLEXES, MAMMALIAN THIOREDOXIN REDUCTASE, AURANOFIN INDUCES APOPTOSIS, OLEFIN METATHESIS CATALYSTS, RUCL CP-ASTERISK, GOLD(I) COMPLEXES, MOTEXAFIN GADOLINIUM, METAL-COMPLEXES, CANCER-CELLS, IN-VITRO
  • İnönü Üniversitesi Adresli: Evet

Özet

In recent years, the preparation of metal complexes and the introduction of biologically active organometalic compounds are new strategies in drug development. For this purpose, generally N-heterocyclic pharmaceutical agents have been used as promising nuclei. Au-containing N-heterocyclic carbene (Au-NHC) derivatives are among the compounds used for this purpose, and their enzyme inhibition, antioxidant activity, antimicrobial and anticancer properties are widely studied. In these studies, the anticancer property of Au-NHC complexes is the most widely studied area. The common result in different studies has been revealed that mitochondrial thioredoxin reductases (TrxR) inhibition is the main pathway in the powerful anticancer effect of many Au-NHC complexes. In TrxR inhibition, the high affinity of gold to sulfur is considered to be the main component of the effect. This review includes the discussions releated to the anticancer activities and TrxR inhibition properties of Au-NHC compounds.