Akademik Veri Yönetim Sistemi
Verhandlungen der Deutschen Gesellschaft für Zytologie (DGZ) 33.Tagung, Hamburg, Almanya, 4 - 06 Eylül 2025, ss.1-2, (Özet Bildiri)
Pulmonary involvement in secondary amyloidosis: a rare case report
Berktaş, M.B.
İnönü University Turgut Özal Medical Center Internal Medicine Department Battalgazi/Malatya/Türkiye
Background
Amyloidosis comprises a group of disorders characterized by the extracellular deposition of amyloid proteins in various tissues and organs.
Case Presentation
We report a rare case of pulmonary amyloidosis in a patient previously diagnosed with secondary amyloidosis. The patient presented with bilateral pretibial edema, and nephrotic syndrome was suspected based on laboratory findings (creatinine: 2.5 mg/dL, albumin: 0.9 g/dL, spot urine microprotein: 572 mg/dL, spot urine creatinine: 43 mg/dL, proteinuria: 11 g/day). A renal biopsy confirmed secondary amyloidosis. During follow-up, the patient developed dyspnea and hemoptysis. Thoracic computed tomography revealed diffuse tubulocystic bronchiectasis in both lungs, predominantly in the middle and lower zones. A VATS wedge resection was performed on the right lung, and histochemical analysis showed Congo red-positive amyloid deposition in vascular walls.
Aim
In this case, we aimed to present a rare case of pulmonary amyloidosis in a patient diagnosed with secondary amyloidosis.
Conclusion
Although systemic amyloidosis commonly affects multiple organs, pulmonary involvement remains rare. Pulmonary amyloidosis should be considered in patients presenting with respiratory symptoms such as dyspnea or hemoptysis, regardless of a prior diagnosis of systemic or secondary amyloidosis.
References
1. Dinur D, Klein Y, Stalnikowicz R, Brezis M. Systemic amyloidosis secondary to tumoral calcinosis. Nephron 1991;59:525-6.
2. Milani P, Basset M, Russo F, Foli A, Palladini G, Merlini G. The lung in amyloidosis. Eur Respir Rev. 2017;26(145):170046.