Association between Serum 25-Hydroxyvitamin D Levels and TTN

Konca C., Kahramaner Z., Bulbul M., Erdemir A., Tekin M., Ercan S., ...More

HORMONE RESEARCH IN PAEDIATRICS, vol.81, no.6, pp.397-401, 2014 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 81 Issue: 6
  • Publication Date: 2014
  • Doi Number: 10.1159/000358521
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.397-401
  • Inonu University Affiliated: No


Aim: To investigate the association between serum 25-hydroxyvitamin D(25(OH)D-3) levels and transient tachypnea of the newborn (TTN). Methods: Calcium (Ca), phosphorus (P), alkaline phosphatase (ALP), parathormone (PTH) and serum 25(OH)D-3 levels were measured in 51 infants diagnosed with TTN and 59 healthy control infants for comparison. Demographic factors including gestational age, birth weight, gender, delivery mode, parity, vitamin D supplementation during pregnancy and severity of TTN were recorded. Results: The serum levels of 25(OH)D-3 were significantly lower in infants with TTN compared to infants with no respiratory distress (p < 0.01). There was no statistically significant difference in serum Ca, P and ALP levels between the groups while the serum levels of PTH were significantly higher in the study group (p < 0.01). No correlation was found between the serum 25(OH)D-3 levels and severity of TTN. Vitamin D supplementation (400 IU/day) during pregnancy did not affect the serum levels of newborns. Conclusion: Our data suggests that lower 25(OH)D-3 serum levels are associated with an increased risk of TTN and vitamin D may have a role in the pathogenesis of TTN. (C) 2014 S. Karger AG, Basel