Akademik Veri Yönetim Sistemi
5th International Organic Chemistry Congress, Malatya, Türkiye, 14 - 17 Ekim 2021, ss.48
Organic and organometallic chemistry was indisputably transformed by Arduengo et al who isolated the first free Nheterocyclic
carbene (NHC) in 1991 [1]. Since then, a large number of different NHCs have been synthesized, and this
important class of ligands has been known as excellent candidates for palladium-catalyzed cross‐coupling reactions due to
their superior performance over the more commonly used tertiary phosphines. These ligands are electron-rich Lewis bases that
benefit from stabilization associated with both strong σ-donor and weak π‐acceptor character [2].
Recently, with the developments, impart unique properties to molecules with fluorine-containing units among numerous
structural motifs have been demanded [3]. As a result of these developments, close to three hundred fluorine-containing drugs
have been approved and used worldwide. Also, half of the drugs containing these fluorine atoms were blockbusters [4].
Acetylcholine (ACh) is a key neurotransmitter in the human body, acting as a biochemical messenger for conveying signals
via the nerve synapse. The significance of central cholinergic transmission has been relevant to a plethora of diseases, like
Parkinson's disease, schizophrenia, Alzheimer's disease (AD), and epilepsy [5]. In our study, we have reported the synthesis and characterization of the trifluoromethoxybenzyl substituted benzimidazolium
salts. Additionally, these compounds were examined against the acetylcholinesterase enzyme.