Ru(II)-NHC catalysed N-Alkylation of amines with alcohols under solvent-free conditions

KARACA E. Ö., Dehimat Z. I., YAŞAR S., GÜRBÜZ N., Tebbani D., Cetinkaya B., ...More

INORGANICA CHIMICA ACTA, vol.520, 2021 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 520
  • Publication Date: 2021
  • Doi Number: 10.1016/j.ica.2021.120294
  • Journal Name: INORGANICA CHIMICA ACTA
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Chemical Abstracts Core
  • Keywords: Amine, Hydrogen auto-transfer method, N-alkylation, Ru(II)-NHC, RUTHENIUM II COMPLEXES, HETEROCYCLIC-CARBENE, BORROWING HYDROGEN, EFFICIENT CATALYSTS, INTRAMOLECULAR HYDROAMINATION, REDUCTIVE AMINATION, OLEFIN METATHESIS, PINCER COMPLEXES, HIGHLY EFFICIENT, AROMATIC-AMINES
  • Inonu University Affiliated: Yes

Abstract

The reaction of [RuCl2(p-cymene)]2 with in situ prepared Ag-N-heterocyclic carbene (NHC) complexes yields a series of [RuCl2(p-cymene)(NHC)] complexes (2). All of the complexes have been characterised by elemental analysis, and 1H NMR and 13C NMR spectroscopies. These complexes have been tested for the N-alkylation of aromatic amines with arylmethyl alcohols under neat conditions in the presence of KOtBu at 120 ?C. Compounds (2) are stable and have high catalytic/selective activity for the N-alkylation reactions of primary amines to afford secondary amines.