Antioxidant effects of N-acetylcysteine in a neonatal rat model of necrotizing enterocolitis


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Ozdemir R. , YURTTUTAN S., SARI F. N. , UYSAL B., UNVERDI H. G. , CANPOLAT F. E. , ...Daha Fazla

JOURNAL OF PEDIATRIC SURGERY, cilt.47, ss.1652-1657, 2012 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 47 Konu: 9
  • Basım Tarihi: 2012
  • Doi Numarası: 10.1016/j.jpedsurg.2012.02.016
  • Dergi Adı: JOURNAL OF PEDIATRIC SURGERY
  • Sayfa Sayıları: ss.1652-1657

Özet

Background/Purpose: Hypoxia and ischemia appear to play an important role in the pathogenesis of necrotizing enterocolitis (NEC), which may be related to oxygen-derived free radical formation. This study was designed to evaluate the role of oxidative stress and potentially beneficial effects of N-acetylcysteine (NAC) in a neonatal rat model of NEC.