Antioxidant effects of N-acetylcysteine in a neonatal rat model of necrotizing enterocolitis


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Ozdemir R., YURTTUTAN S., SARI F. N., UYSAL B., UNVERDI H. G., CANPOLAT F. E., ...More

JOURNAL OF PEDIATRIC SURGERY, vol.47, no.9, pp.1652-1657, 2012 (SCI-Expanded, Scopus)

  • Publication Type: Article / Article
  • Volume: 47 Issue: 9
  • Publication Date: 2012
  • Doi Number: 10.1016/j.jpedsurg.2012.02.016
  • Journal Name: JOURNAL OF PEDIATRIC SURGERY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1652-1657
  • Inonu University Affiliated: Yes

Abstract

Background/Purpose: Hypoxia and ischemia appear to play an important role in the pathogenesis of necrotizing enterocolitis (NEC), which may be related to oxygen-derived free radical formation. This study was designed to evaluate the role of oxidative stress and potentially beneficial effects of N-acetylcysteine (NAC) in a neonatal rat model of NEC.