Antioxidant effects of N-acetylcysteine in a neonatal rat model of necrotizing enterocolitis

Ozdemir, RAMAZAN; YURTTUTAN, Sadik; SARI, Fatma; UYSAL, Bulent; UNVERDI, Hatice; CANPOLAT, Fuat; ERDEVE, Omer; DILMEN, Ugur

doi:10.1016/j.jpedsurg.2012.02.016

Antioxidant effects of N-acetylcysteine in a neonatal rat model of necrotizing enterocolitis

Ozdemir R., YURTTUTAN S., SARI F. N., UYSAL B., UNVERDI H. G., CANPOLAT F. E., ...More

JOURNAL OF PEDIATRIC SURGERY, vol.47, no.9, pp.1652-1657, 2012 (SCI-Expanded, Scopus)

Publication Type: Article / Article
Volume: 47 Issue: 9
Publication Date: 2012
Doi Number: 10.1016/j.jpedsurg.2012.02.016
Journal Name: JOURNAL OF PEDIATRIC SURGERY
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.1652-1657
Inonu University Affiliated: Yes

Abstract

Background/Purpose: Hypoxia and ischemia appear to play an important role in the pathogenesis of necrotizing enterocolitis (NEC), which may be related to oxygen-derived free radical formation. This study was designed to evaluate the role of oxidative stress and potentially beneficial effects of N-acetylcysteine (NAC) in a neonatal rat model of NEC.