Synthesis, cytotoxic and antimicrobial activities of novel cobalt and zinc complexes of benzimidazole derivatives

APOHAN E., Yilmaz U., Yilmaz O., SERINDAG A., KÜÇÜKBAY H., YEŞİLADA Ö., ...Daha Fazla

JOURNAL OF ORGANOMETALLIC CHEMISTRY, cilt.828, ss.52-58, 2017 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 828
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1016/j.jorganchem.2016.11.020
  • Dergi Adı: JOURNAL OF ORGANOMETALLIC CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.52-58
  • Anahtar Kelimeler: Benzimidazole complexes, Cytotoxic, Lung cancer, Antimicrobial, CELL LUNG-CANCER, SUBSTITUTED BENZIMIDAZOLE, STRUCTURAL-CHARACTERIZATION, BIOLOGICAL EVALUATION, METAL-COMPLEXES, IN-VITRO, ANTICANCER, IMIDAZOLE, APOPTOSIS, DESIGN
  • İnönü Üniversitesi Adresli: Evet

Özet

In this study fourteen novel cobalt (II) or zinc (II) complexes of benzimidazoles were synthesized from the 1-(4-substitutedbenzyl)-1H-benzimidazoles and CoCl2.6H(2)O or ZnCl2. Cytotoxic activities of novel complexes were investigated against lung cancer cells (A549) and BEAS-2B. Three of the examined compounds (1, 4 and 5) showed high cytotoxic activity against A549. While the IC50 of the cisplatin was 2.56 pg/mL for A549 cells at 72 h, the IC50 values of compounds 1, 4 and 5 were 1.97, 1.87 and 1.9 mu g/mL, respectively. IC50 values of these compounds for BEAS-2B cells were higher than the IC50 values for A549. While the IC50 values for BEAS-2B cells were 59.8, 24.5 and 32.67 mu g/mL, respectively, the IC50 of the cisplatin was determined as 2.53 pgimL in the present work. Three of the compounds have also high antimicrobial activity against all the microorganisms used. (C) 2016 Elsevier B.V. All rights reserved.