Surgical Removal of Endometrioma Decreases the NF-kB1 (p50/105) and NF-kB p65 (Rel A) Expression in the Eutopic Endometrium During the Implantation Window
REPRODUCTIVE SCIENCES, cilt.20, sa.7, ss.762-770, 2013 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 20 Sayı: 7
- Basım Tarihi: 2013
- Doi Numarası: 10.1177/1933719112466307
- Dergi Adı: REPRODUCTIVE SCIENCES
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.762-770
- Anahtar Kelimeler: endometrioma, eutopic endometrium, laparoscopy, NF-kB1, NF-kB p65 (Rel A), FACTOR-KAPPA-B, LAPAROSCOPIC OVARIAN CYSTECTOMY, ALPHA-V-BETA-3 INTEGRIN EXPRESSION, IN-VITRO FERTILIZATION, DECIDUAL PROLACTIN, DNA METHYLATION, SEX STEROIDS, CROSS-TALK, WOMEN, HOXA10
- İnönü Üniversitesi Adresli: Evet
Özet
We aimed to investigate whether the surgical removal of endometrioma alters the nuclear factor-kappa B1 (NF-kB1; p50/105) and NF-kB p65 (Rel A) expression in the eutopic endometrium of infertile women with endometrioma before and after laparoscopic removal of the ovarian endometrioma during the mid-secretory phase. Infertile women with endometrioma (n = 15) were enrolled. Infertile patients with nonendometriotic ovarian cyst (n = 10) and healthy fertile women (n = 10) were recruited as controls. Endometrial samples were obtained before and 3 months after the laparoscopic cystectomy. The NF-kB1 (p50/105) levels were analyzed by enzyme-linked immunosorbent assay (ELISA) in the endometrium of all groups before and after laparoscopic ovarian cystectomy during implantation window. Expression of NF-kB1 (p50/105) in eutopic endometrium was significantly higher in infertile women with endometrioma compared to nonendometriotic cyst and fertile controls (P < .05). Laparoscopic cystectomy resulted in a significant decrease in NF-kB1 expression in women with endometrioma. The NF-kB p65 (Rel A) immunoreactivity of eutopic endometrium decreased significantly subsequent to the surgical removal of the endometrioma. In conclusion, increased endometrial NF-kB expression may contribute to endometriosis-associated infertility.