Fuzzy clustering based regression analysis is a novel hybrid approach to capture the linear structure while considering the classification structure of the measurement. Using the concept that weights provided via the fuzzy degree of clustering, some regression models have been proposed in literature. In these models, membership values derived from clustering or some weights obtained from geometrical functions are employed as the weights of regression system. This paper addresses a weighted fuzzy regression analysis based on spatial dependence measure of the memberships. By the methodology presented in this paper, the relative weights are used in fuzzy regression models instead of direct membership values or their geometrical transforms. The experimental studies indicate that the spatial dependence based analyses yield more reliable results to show the correlation of the independent variables into the dependent variable. In addition, it has been observed that spatial dependence based models have high estimation and generalization capacities. (C) 2011 Elsevier B.V. All rights reserved.