Neuroprotective effect of etomidate on functional recovery in experimental spinal cord injury

Cayli, Suleyman; Ates, Ozkan; Karadag, NEŞE; Altinoz, Eyup; Yucel, NESLİHAN; Yologlu, SAİM; Kocak, Ayhan; Cakir, Celal

doi:10.1016/j.ijdevneu.2006.04.003

Neuroprotective effect of etomidate on functional recovery in experimental spinal cord injury

Cayli S. R., Ates O., Karadag N., Altinoz E., Yucel N., Yologlu S., ...Daha Fazla

INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE, cilt.24, sa.4, ss.233-239, 2006 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 24 Sayı: 4
Basım Tarihi: 2006
Doi Numarası: 10.1016/j.ijdevneu.2006.04.003
Dergi Adı: INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.233-239
İnönü Üniversitesi Adresli: Evet

Özet

Objective: Primary impact to the spinal cord causes rapid oxidative stress after injury. To protect neural tissue, it is important to prevent secondary pathophysiological mechanisms. Etomidate, a strong antiexcitotoxic agent, stimulates the gamma aminobutyric acid (GABA) receptors. The purpose of this study was to investigate neurobehavioral and histological recovery and to evaluate the biochemical responses to treatment of experimental spinal cord injury (SCI) in rats with etomidate or methylprednisolone (MP) or both etomidate and MP.