Neuroprotective effect of etomidate on functional recovery in experimental spinal cord injury


Cayli S. R., Ates O., Karadag N., Altinoz E., Yucel N., Yologlu S., ...More

INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE, vol.24, no.4, pp.233-239, 2006 (SCI-Expanded) identifier identifier identifier

Abstract

Objective: Primary impact to the spinal cord causes rapid oxidative stress after injury. To protect neural tissue, it is important to prevent secondary pathophysiological mechanisms. Etomidate, a strong antiexcitotoxic agent, stimulates the gamma aminobutyric acid (GABA) receptors. The purpose of this study was to investigate neurobehavioral and histological recovery and to evaluate the biochemical responses to treatment of experimental spinal cord injury (SCI) in rats with etomidate or methylprednisolone (MP) or both etomidate and MP.