Neuroprotective effect of etomidate on functional recovery in experimental spinal cord injury


Cayli S. R. , Ates O., Karadag N. , Altinoz E., Yucel N. , Yologlu S. , ...Daha Fazla

INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE, cilt.24, ss.233-239, 2006 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 24 Konu: 4
  • Basım Tarihi: 2006
  • Doi Numarası: 10.1016/j.ijdevneu.2006.04.003
  • Dergi Adı: INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE
  • Sayfa Sayıları: ss.233-239

Özet

Objective: Primary impact to the spinal cord causes rapid oxidative stress after injury. To protect neural tissue, it is important to prevent secondary pathophysiological mechanisms. Etomidate, a strong antiexcitotoxic agent, stimulates the gamma aminobutyric acid (GABA) receptors. The purpose of this study was to investigate neurobehavioral and histological recovery and to evaluate the biochemical responses to treatment of experimental spinal cord injury (SCI) in rats with etomidate or methylprednisolone (MP) or both etomidate and MP.