Prevention of renal ischemia/reperfusion-induced injury in rats by leflunomide.

Karaman A., Turkmen E., Gursul C., Tas E., Fadillioglu E.

International journal of urology : official journal of the Japanese Urological Association, cilt.13, sa.11, ss.1434-41, 2006 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 13 Sayı: 11
  • Basım Tarihi: 2006
  • Doi Numarası: 10.1111/j.1442-2042.2006.01592.x
  • Dergi Adı: International journal of urology : official journal of the Japanese Urological Association
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1434-41
  • Anahtar Kelimeler: leflunomide, nitric oxide, oxidant/antioxidant, reactive oxygen species, renal ischemia reperfusion, ISCHEMIA-REPERFUSION INJURY, ACID PHENETHYL ESTER, ACTIVE RHEUMATOID-ARTHRITIS, NF-KAPPA-B, NITRIC-OXIDE, IN-VIVO, LIPID-PEROXIDATION, OXIDATIVE STRESS, DYSFUNCTION, KIDNEY
  • İnönü Üniversitesi Adresli: Evet

Özet

Objective: There is increasing evidence to suggest that toxic oxygen radicals play an essential role in the pathogenesis of ischemia/reperfusion (I/R) injury in the kidney. This study was designed to investigate the effects of leflunomide, an isoxazole derivative and a unique immunomodulatory agent, in I/R-induced renal injury in rats.