Prevention of renal ischemia/reperfusion-induced injury in rats by leflunomide


Karaman A., Turkmen E., Gursul C., Tas E., Fadillioglu E.

INTERNATIONAL JOURNAL OF UROLOGY, cilt.13, ss.1434-1441, 2006 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 13 Konu: 11
  • Basım Tarihi: 2006
  • Doi Numarası: 10.1111/j.1442-2042.2006.01592.x
  • Dergi Adı: INTERNATIONAL JOURNAL OF UROLOGY
  • Sayfa Sayıları: ss.1434-1441

Özet

Objective: There is increasing evidence to suggest that toxic oxygen radicals play an essential role in the pathogenesis of ischemia/reperfusion (I/R) injury in the kidney. This study was designed to investigate the effects of leflunomide, an isoxazole derivative and a unique immunomodulatory agent, in I/R-induced renal injury in rats.