High-sensitivity electrochemical sensor using no nanomaterials for the detection of ciprofloxacin with poly 2-(hydroxymethyl)thiophene-modified glassy carbon electrode

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Burç M., Güngör Ö., Titretir Duran S.

POLYMER BULLETIN, cilt.1, ss.1-29, 2023 (SCI-Expanded)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 1
  • Basım Tarihi: 2023
  • Doi Numarası: 10.1007/s00289-023-04995-z
  • Dergi Adı: POLYMER BULLETIN
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, PASCAL, Chemical Abstracts Core, Chimica, Compendex, INSPEC
  • Sayfa Sayıları: ss.1-29
  • İnönü Üniversitesi Adresli: Evet

Özet

Abstract

In this study, a new sensor was developed for the detection of ciprofloxacin that is easy to prepare, selective and has excellent sensitivity through electrochemical

polymerization of 2-(hydroxymethyl)thiophene on glassy carbon (GC) electrode. Electrode modifications were performed by using cyclic voltammetry. The morphology

and surface properties of the modified electrode were characterized by using scanning electron microscopy. Determination of ciprofloxacin with poly 2-(hydroxymethyl)

thiophene-modified GC electrode was performed by square wave voltammetry in 0.1 M citrate buffer (pH 5.00) at 1.1 V. The prepared sensor showed a wide

linear range from 0.1 to 200 μM, detection limit of 7 nM, a limit of quantitation of 22 nM, a correlation coefficient of 0.9993, excellent sensitivity of 99.6% and a relative

standard deviation of 0.40%. The sensor was used to determine ciprofloxacin in human urine samples, and a recovery efficiency of 99.24–100.36% was obtained.

According to the results in this study, we believe that the sensor developed can be used for the detection of ciprofloxacin in clinical laboratories.