Investigation of the relationship between obesity and rs9939609 and rs1421085 single nucleotide polymorphisms in the FTO gene


Culum A. A. , Yürekli M.

INTERNATIONAL EURASIAN CONFERENCE ON BIOTECHNOLOGY AND BIOCHEMISTRY, Ankara, Türkiye, 16 - 18 Aralık 2020, ss.28

  • Basıldığı Şehir: Ankara
  • Basıldığı Ülke: Türkiye
  • Sayfa Sayıları: ss.28

Özet

Body mass index between 25-29.9 kg/m² reflects overweight, 30-39.9 kg/m² obese, 40 kg/m² and above represent morbid obesity. FTO (fat mass and obesity associated gene) is the first obesity susceptibility gene discovered during genome-wide association studies. Today, it continues to be the gene locus with the broadest impact on body mass index (BMI). It is the most variable gene region in different lineages throughout life, depending on various types of obesity. One hundred and forty-two overweight and obese (BMI≥25 kg/m2 ), and 142 healthy individuals (BMI <25 kg / m2 ) as a control from the Turkish population living in Malatya were included in the study. The rs9939609 and rs1421085 genotypes were detected by the PCR-RFLP method. Obese and control groups were compared for possible differences between genotype and allele distributions. Besides, whether there is a relationship between rs9939609 and rs1421085 and BMI was investigated. The obese-control study showed that there was no significant difference between the obese and control groups screened in terms of genotypic and allelic distributions of rs9939609 and rs1421085 single nucleotide polymorphisms. Additionally, no relationship was found between rs9939609 and rs1421085 and BMI.