Mutations in GNA11 in Uveal Melanoma.

Van Raamsdonk, Catherine; Griewank, Klaus; Crosby, Michelle; Garrido, Maria; Vemula, Swapna; Wiesner, Thomas; Obenauf, Anna; Wackernagel, Werner; Green, Gary; Bouvier, Nancy; Sozen, MUSTAFA; Baimukanova, Gail; Roy, Ritu; Heguy, Adriana; Dolgalev, Igor; Khanin, Raya; Busam, Klaus; Speicher, Michael; O'brien, Joan; Bastian, Boris

doi:10.1056/nejmoa1000584

Mutations in GNA11 in Uveal Melanoma.

Van Raamsdonk C. D., Griewank K. G., Crosby M. B., Garrido M. C., Vemula S., Wiesner T., ...Daha Fazla

NEW ENGLAND JOURNAL OF MEDICINE, cilt.363, sa.23, ss.2191-2199, 2010 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 363 Sayı: 23
Basım Tarihi: 2010
Doi Numarası: 10.1056/nejmoa1000584
Dergi Adı: NEW ENGLAND JOURNAL OF MEDICINE
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.2191-2199
İnönü Üniversitesi Adresli: Hayır

Özet

Background: Uveal melanoma is the most common intraocular cancer. There are no effective therapies for metastatic disease. Mutations in GNAQ, the gene encoding an alpha subunit of heterotrimeric G proteins, are found in 40% of uveal melanomas.