Mutations in GNA11 in Uveal Melanoma.


Van Raamsdonk C. D. , Griewank K. G. , Crosby M. B. , Garrido M. C. , VEMULA S., Wiesner T., ...Daha Fazla

NEW ENGLAND JOURNAL OF MEDICINE, cilt.363, ss.2191-2199, 2010 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 363 Konu: 23
  • Basım Tarihi: 2010
  • Doi Numarası: 10.1056/nejmoa1000584
  • Dergi Adı: NEW ENGLAND JOURNAL OF MEDICINE
  • Sayfa Sayıları: ss.2191-2199

Özet

Background: Uveal melanoma is the most common intraocular cancer. There are no effective therapies for metastatic disease. Mutations in GNAQ, the gene encoding an alpha subunit of heterotrimeric G proteins, are found in 40% of uveal melanomas.