Neopterin Levels and Indoleamine 2,3-Dioxygenase Activity as Biomarkers of Immune System Activation and Childhood Allergic Diseases


ÜNÜVAR S. , Erge D., Kilicarslan B., Bag H. G. G. , ÇATAL F., GİRGİN G., ...Daha Fazla

ANNALS OF LABORATORY MEDICINE, cilt.39, ss.284-290, 2019 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 39 Konu: 3
  • Basım Tarihi: 2019
  • Doi Numarası: 10.3343/alm.2019.39.3.284
  • Dergi Adı: ANNALS OF LABORATORY MEDICINE
  • Sayfa Sayıları: ss.284-290

Özet

Background: Although Th2 immune activation is predominant in allergic diseases, neopterinlevels and indoleamine 2,3-dioxygenase (IDO)-1 activity (kynurenine:tryptophan ratio), which reflect Th1 immune activity, increase with interferon-gamma (IFN-gamma) stimulation. We investigated neopterin, tryptophan, and kynurenine levels as biomarkersof the Th1 immune system activation and changes in IDO-1 activityin children with asthma, allergic rhinitis, and atopic dermatitis, as well as the relationship between these biomarkers and the total IgE level, age, and disease severity.