Objective: In this study, we proposed that if schizophrenic symptoms will decrease with drug treatment, it would be improvement in attention and memory functions. Method: This research has been done in Inonu University Turgut Ozal Medicine Center Psychiatry Clinic between 2003-2005. We included 27 patients whose ages ranged between 18-50 and who were inpatients and/or outpatients of Psychiatry Clinic, treated with the diagnosis of schizophrenia according to DSM-IV diagnosis criteria. During their acute periods Brief Psychiatric Rating Scale (BPRS), Positive Symptoms Rating Scale (SAPS), Negative Symptoms Rating Scale (SANS) and UKU Side Affect Assessment Inquiry were applied to patients and, at the same day they were also given Wechsler Memory Scale (WMS-R), Stroop Test and a Verbal Test of Memory Process (SBST). Same procedures were repeated when their symptoms improvement (when their BPRS scores were reduced at least % 50). By using Wilcoxon Signed Ranks Test, we compared psychometric measures that were performed in patients in two periods. Results: When the results of neuropsychological tests in the acute and symptom resolution periods were compared, in WMS-R test; personal and current information task, orientation, concentration, logical memory and attention scores, in SBST; long and short period memory scores were found significantly higher, and all Stroop subtest scores were found significantly lower in the response to treatment. Conclusion: In our study, we found that schizophrenia patients have better attention and memory functions when positive and negative symptoms were regressed. This observation supports the importance of prevention of exacerbations in terms of reduction cognitive deteriorations in patients with schi zophrenia.