Synthesis, characterization and antitumor properties of novel silver(I) and gold(I) N-heterocyclic carbene complexes

ÖZDEMİR İ., ÇİFTÇİ O., Evren E., GÜRBÜZ N., Kaloglu N., BAŞAK TÜRKMEN N., ...Daha Fazla

INORGANICA CHIMICA ACTA, cilt.506, 2020 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 506
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1016/j.ica.2020.119530
  • Dergi Adı: INORGANICA CHIMICA ACTA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Chimica
  • Anahtar Kelimeler: N-heterocyclic carbene, Benzimidazolium salts, Silver- and gold NHC complexes, Antitumor activity, CATALYTIC TRANSFER HYDROGENATION, STRUCTURAL-CHARACTERIZATION, COUPLING REACTIONS, DIRECT ARYLATION, ANTICANCER, PALLADIUM, CISPLATIN, LIGANDS, AGENTS, MECHANISMS
  • İnönü Üniversitesi Adresli: Evet

Özet

In this study, two novel benzimidazolium salts consisting propane sulfonate order were integrated in high yields as N-heterocyclic carbene (NHC) precursors. The silver-NHC buildings were set up by responding 1-(2,2-dimethoxyahyl)-3-(propyl-3-sulfonate)benzimidazolium and 1-(2,2-diethoxyahyl)-3-(propyl-3-sulfonate)benzimidazolium with silver oxide on average state. Gold-NHC edifices were acquired by means of transmetallation of their silver precursors with [AuCl{S(CH3)(2)}]. The structures of all mixes were completely portrayed by spectroscopic techniques H-1 NMR, C-13{1H} NMR, IR and elemental and further analyzed by DFT/TDDFT strategies. IC50 values and cytotoxic impacts of these four complexes were controlled by the MTS put together examine with respect to three human cancer cell lines neuroblastoma (SHSY5Y), adenocarcinoma (HEP3B), and human fibroblasts (HF).